Gut → Skin
When the gut's tight junctions loosen, lipopolysaccharides escape into circulation and trigger a body-wide inflammatory cascade. In melanated skin, this expresses as deeper hyperpigmentation and eczema patches that resist topical treatment alone.
- 1Leaky gut barrier↓
- 2Systemic LPS endotoxemia↓
- 3Pro-inflammatory cytokine flood↓
- 4Melanocyte hyper-stimulation↓
- 5Worsened PIH & eczema flares